@AnKing-Maintainers I’m a bit removed from this content now, can anyone double check me so we can close this out? Original extra I’m pretty sure is just wrong/wordy
@CTE_BrainDamage Amboss: Because sulfonylureas are excreted via the kidneys, renal failure can result in accumulation. Hypoglycemia due to accumulation of long-acting glyburide may persist for several days, requiring extensive glucose substitution. Short-acting agents have a lower risk of accumulation and hypoglycemia.
So that’s the part that was originally correct about the Extra here; my understanding is that they are metabolized by the liver, though, which is the main thing I’m trying to correct
When you look at the top link, both renal AND liver failure are contraindications - I think that this change is accurate and makes everything more concise. Can add second bullet that liver failure is also a contraindication
Agree with @herstein.jacob, Amboss mentions inhibitors of CYP2C9 (eg, amiodarone, trimethoprim, fluconazole) increase the risk of life-threatening hypoglycemia
@AnKing-Maintainers edited for completeness - let’s close this out