support, i think we can keep it as muscarinic antagonist just remove m1? or mention nonselective muscarinic antagonist in text. @CTE_BrainDamage @herstein.jacob @shmuelsash @Stillmatic @Tahseen @Bilal
The vomiting center of the brain is located in the medulla oblongata and contains a high amount of M1 muscarinic acetylcholine, H1 histamine, NK1, and 5-HT3 serotonin receptors. Thus, any agent that antagonizes these receptors will have antiemetic properties. Scopolamine exerts its action by primarily affecting the M1 receptor. However, some research has reported H1 receptor activity.
Take both with a grain of salt.
Scopolamine competitively inhibits G-protein coupled post-ganglionic muscarinic receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both peripheral antimuscarinic properties and central sedative, antiemetic, and amnestic effects
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