Original source for the card is Pathoma (pg42): Under “ANEMIA OF CHRONIC DISEASE” it says "Chronic disease results in production of acute phase reactants from the liver, including hepcidin.
- Hepcidin sequesters iron in storage sites by (1) limiting iron transfer from
macrophages to erythroid precursors and (2) suppressing erythropoietin (EPO)"
Not speaking to either source, I just know where the card came from.
AMBOSS supports the original card: https://next.amboss.com/us/article/6T0j72?q=hepcidin#P01WT20
I think I see the contradiction now.
From what I can tell, in normal physiology, EPO directly suppresses hepcidin via erythroferrone to increase access to iron. But in chronic inflammation (anemia of chronic disease), IL-6 stimulates hepcidin to a point where iron levels are decreased so much that hepcidin indirectly blunts the hematopoietic effects of EPO
This is way too complicated for step 1, I think perhaps a better change would be: In chronic inflammation, hepcidin suppresses the effects of erythropoietin (EPO) - and then add e.g., anemia of chronic disease in the extra- thought on this?