can you please paste the uworld educational objective statement
Transporter associated with antigen processing (TAP) proteins are necessary for loading of cytoplasmic (eg, viral) proteins onto major histocompatibility complex (MHC) class I molecules. The MHC class I–peptide complex can then activate CD8+ cytotoxic T cells through interaction with the T cell receptor and CD8 coreceptor.
let me think about it and analyze the sister cards to see if there is a way around making a new cloze. will do it if it is truly necessary
The answer options in UWorld specifically test if you know if it’s MHC II or MHC I.
(Choice D) MHC class II molecules are expressed on antigen-presenting cells (eg, macrophages, B cells) after phagocytized proteins are degraded within lysosomes and added to MHC class II molecules. T helper (CD4+) cells are activated by the MHC class II–peptide complex and coordinate the adaptive immune response. TAP does not play a role in antigen loading of MHC class II molecules.
@alexander if that is the case I think the extras section needs some clarifying “in contrast to MHC II…etc…” Are you able to review that uworld question in more detail and make a recommendation to what that extras contrast should be?
Hi, see my updated extra suggestions with additional citations on MHC II mechanisms.
it cant be uworld word for word, needs some paraphrasing
Paraphrased.