Confused about a question intra vs extravascular hemolysis and jaundice

đź“– AnkiHub Decks
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Normocytic anemia with extravascular hemolysis is associated with {{c1::jaundice}} due to increased serum {{c2::unconjugated bilirubin}}
Extra
Increased unconjugated bilirubin overloads the conjugating ability of the liver

Anki id: 1478915732347

So what’s the point of this question? What are we learning here? Isn’t this true for intravascular hemolysis too?

Also what’s with the normocytic? Isn’t this true for macrocytic and microcytic?

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The point of the question is to associate the key feature of extravascular hemolysis as being predominantly unconjugated hyperbilirubinemia.

Unconjugated can occur in intravascular, but is more characteristic of extravascular (intravscular hemolysis will be defined by primary findings of free hemoglobin, rather than just bilirubin). Thus, the characteristic presentation is more indicative of extravascular hemolysis.

While bilirubin elevation can also occur in macrocytic and microcytic, it’s not in those cases typically the result of hemolysis and thus not the focus of the information presented. In this case, the anemia being normocytic links it to hemolysis and not present issues of erythrocyte size, production, etc.

Hopefully that helps. :slight_smile:

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I see! Thanks for the response very helpful!

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