[02.11.2023] Updated content, AnKing Overhaul for Step 1 & 2/AnKingMed, ID 236029

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https://next.amboss.com/us/article/Tm06Ug?q=andexanet+alfa#Z553b17c60bdb51e96d3a63431b3d766a

Still hard to reverse and very expensive from my understanding. Will check the link later

nothing in link states that it is easy to reverse, but just that they are available. in other papers, "Andexanet was found to reverse the anticoagulant effects of apixaban and rivaroxaban within two minutes of administration, an effect that was maintained for the duration of the infusion " (paper:Direct-Acting Oral Anticoagulants and Their Reversal Agents—An Update - PMC) and a paper on the cost effectiveness of andexanet alfa reversal for intracranial hemorrhage stated: “The analysis showed that the strategy of using andexanet alfa for the treatment of factor Xa inhibitor-related ICH is cost-effective, with incremental cost-effectiveness per quality-adjusted life-year gained of $35,872 from a third-party payer perspective and $40,997 from a societal perspective over 20 years.” (paper: https://www.tandfonline.com/doi/full/10.1080/13696998.2022.2042106)

not many papers are available regarding this but the efficacy for andexanet is much better it seems, but it still is cost prohibitive in certain situations, so whether it is easily reversible comes down to whether you’re asking about availability and cost of drug or whether the drug itself is good at reversing the effect, which so far it seems that it is

Yes but AMBOSS has it highlighted + high yield mode shows that it is the corresponding reversible agent. It may be that it is expensive and not necessarily as effective as others but for step purposes… :slight_smile:

Modified to reflect above