@Brian_BH , I absolutely love how well-written this rationale is. We, as maintainers, LOVE this!! Just wanted to ask if 401885 is a relevant QID. If so, what is the rationale behind it?
It is. 
For 401885, the question requires the knowledge of how a changing pH will affect protonation of a given example molecule, specifically in relation to the given pka values of its R group. Requires the understanding that raising the pH, relative to the pka, will cause deprotonation and subsequent alteration of charge (negative, in this case) relative to the starting pH, in order to select from multiple answer options with different charges (or neutral).