[03.04.2024] Content error, AnKing Overhaul for Step 1 & 2/AnKingMed, ID 1157509

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The extra section definitely needs clarification but the card is technically correct. Also please use an acceptable source next time.

Under aerobic conditions, the NADH is used in the ETC to make ATP
Under anaerobic conditions, the NADH is not able to be used in the ETC and thus is oxidized back to NAD+ (in order to regenerate it) via the reduction of pyruvate for lactate (thus the entire point of the lactic acid cycle AKA to regenerate NAD+)

FA completely ignores this and just talks about aerobic but doesn’t specify, AMBOSS states the difference between lactate and pyruvate production but only in the image does it show NADH production (that being said this is probably SUPER low yield) - However, if you look at research articles explain in better detail:

“Glycolysis occurs in both aerobic and anaerobic states. In aerobic conditions, pyruvate enters the citric acid cycle and undergoes oxidative phosphorylation leading to the net production of 32 ATP molecules. In anaerobic conditions, pyruvate converts to lactate through anaerobic glycolysis. Anaerobic respiration results in the production of 2 ATP molecules” - Biochemistry, Glycolysis - StatPearls - NCBI Bookshelf.

This article also explains pretty well: Biochemistry, Anaerobic Glycolysis - StatPearls - NCBI Bookshelf

Also to clarify further - the reason aerobic produces 32 and anerobic produces 2 is because of the inability of NADH to be utilized (and thus is “wasted”) and isntead used to regenerate NAD+ → so yes, it does produce 2 NADH but it is not used to create energy and thus the “net” is 0

Also i think its really confusing that we have cards about anaerobic glycolysis but not aerobic (this and nid:1474164557796) → the extra section of both of these cards should compare the aerobic vs anaerbic