The pathway is the hypothalamic–pituitary–adrenal (HPA) axis. Nid 1554605273056 has an image of the HPA axis in Extra. With the suggested 1555173002496 note, it does mention pituitary & adrenal but it’s seems optimal to have content in the card that connects these two and the hypothalamus in their pathway, the HPA axis. Could you submit a separate suggestion for nid 1555173002496? Or feel free to let me know if there’s a reason why you’d prefer 1555173002496 for tagging.
Also, could you share rationale for 401385 in your reply or the new suggestion?
Hey @Brian_BH , just following up
I got you. I will submit here in just a second. 
QID 401385:
Question stem asks what likely effect a reduction of ACTH would have on the kidney. The correct answer option is that it would decrease cortisol release from the adrenal gland, requiring that discrete knowledge.
Inappropriate answer options either mis-state that relationship, refer to unrelated organ systems given the stem information, or mis-pair the appropriate organ with the appropriate hormone altogether.
Updated the other one. 
Thanks! And I realized that I should’ve asked for a new suggestion to nid 1554605273056. I mentioned the same nid as this card. My bad about that!
I double-checked, but I think I nabbed the right one just now.
Yup, that’s the one. For QID 401385, I just realized that we previously had it tagged on. I’m not sure why it showed as a changed tag, but since we have it, I’ll close out this suggestion