Uworld QID 17780: This patient has jaundice and hemolytic anemia a week after a transfusion, findings suggestive of a delayed hemolytic transfusion reaction (DHTR). This reaction occurs in patients who were previously exposed to a foreign, minor red blood cell (RBC) antigen (non-ABO) via mechanisms such as pregnancy, prior transfusion, or intravenous drug use. During the first exposure, only a low, typically undetectable, antibody response is initially mounted. On reexposure via transfusion, the patient’s memory B cells produced a larger surge of antibodies, resulting in detectable hemolysis. This is known as an anamnestic response.
I tried to match the style of the existing cards that cover the other forms of transfusion reaction. delayed hemolytic reaction was just left off for some reason